Publikationen

Veröffentlichungen A - Z

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Prof. Dr. rer. nat. Nico Scheer

Weitere Publikationen

Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice OPUS
Kapelyukh, Yury ; Henderson, Colin James ; Scheer, Nico ; Rode, Anja ; Wolf, Charles Roland (2019)
Drug Metabolism and Disposition. . (2019), H. Early view. - 43 Seiten
An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials OPUS
Scheer, Nico ; Henderson, Colin James ; Kapelyukh, Yury ; Rode, Anja ; Mclaren, Aileen W. ; MacLeod, Alastair Kenneth ; Lin, De ; Wright, Jayne ; Stanley, Lesley ; Wolf, C. Roland (2019)
Drug Metabolism and Disposition. . (2019), H. Early view. - 69 Seiten
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism OPUS
Kazuki, Yasuhiro ; Kobayashi, Kaoru ; Hirabayashi, Masumi ; Abe, Satoshi ; Kajitani, Naoyo ; Kazuki, Kanoko ; Takehara, Shoko ; Takiguchi, Masato ; Satoh, Daisuke ; Kuze, Jiro ; Sakuma, Tetsushi ; Kaneko, Takehito ; Mashimo, Tomoji ; Osamura, Minori ; Hashimoto, Mari ; Wakatsuki, Riko ; Hirashima, Rika ; Fujiwara, Ryoichi ; Deguchi, Tsuneo ; Kurihara, Atsushi ; Tsukazaki, Yasuko ; Senda, Naoto ; Yamamoto, Takashi ; Scheer, Nico ; Oshimura, Mitsuo (2019)
PNAS Proceedings of the National Academy of Sciences of the United States of America. 2019. Seite: 3072 - 3081
The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice OPUS
Wilson, Claire E. ; Dickie, Anthony P. ; Schreiter, Kay ; Wehr, R. ; Wilson, E. M. ; Bial, John ; Scheer, Nico ; Wilson, Ian D. ; Riley, R. J. (2018)
Archives of Toxicology. : Springer. 92 (2018), H. 6. Seite: 1953 - 1967
Genetically Humanized Animal Models OPUS
Samuelsson, K. ; Scheer, Nico ; Wilson, I. ; Wolf, C.R. ; Henderson, C.J. (2017)
Comprehensive Medicinal Chemistry III. 3rd Edition. Saint Louis : Elsevier 2017. Seite: 130 - 149
The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice OPUS
Wilson, Ian D. ; Wilson, Claire E. ; Scheer, Nico ; Dickie, Anthony P. ; Schreiter, Kay ; Wilson, E. M. ; Riley, R. J. ; Wehr, R. ; Bial, John (2017)
Biochemical pharmacology. Amsterdam : Elsevier. Volume 135 (2017). Seite: 139 - 150
A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity OPUS
Scheer, Nico ; Wilson, Ian D. (2016)
Drug Discovery Today. Amsterdam : Elsevier. 21 (2016), H. 2. Seite: 250 - 263
Knockout and humanized animal models to study membrane transporters in drug development OPUS
Buch-Cover
Scheer, Nico ; Chu, Xiaoyan ; Salphati, Laurent ; Zamek-Gliszczynski, Maciej J. (2016)
Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development. Cambridge : Royal Society of Chemistry 2016. Seite: 298 - 332
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling OPUS
Zhang, Jin ; Heimbach, Tycho ; Scheer, Nico ; Barve, Avantika ; Li, Wenkui ; Lin, Wen ; He, Handan (2016)
Journal of Pharmaceutical Sciences. Amsterdam : Elsevier. Volume 105 (2016), H. Issue 4. Seite: 1398 - 1404
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model OPUS
Dallas, Shannon ; Salphati, Laurent ; Gomez-Zepeda, David ; Wanek, Thomas ; Chen, Liangfu ; Chu, Xiaoyan ; Kunta, Jeevan ; Mezler, Mario ; Menet, Marie-Claude ; Chasseigneaux, Stephanie ; Declèves, Xavier ; Langer, Oliver ; Pierre, Esaie ; DiLoreto, Karen ; Hoft, Carolin ; Laplanche, Loic ; Pang, Jodie ; Pereira, Tony ; Andonian, Clara ; Simic, Damir ; Rode, Anja ; Yabut, Jocelyn ; Zhang, Xiaolin ; Scheer, Nico (2016)
Molecular Pharmacology. Bethesda, Md. : ASPET. 89 (2016), H. 5. Seite: 492 - 504
Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs OPUS
Wolf, C. Roland ; Kapelyukh, Yury ; Scheer, Nico ; Henderson, Colin J. (2015)
Cambridge : RSC Publ. 2015. Seite: 152 - 176
Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model OPUS
Scheer, Nico ; Kapelyukh, Yury ; Rode, Anja ; Oswald, Stefan ; Busch, Diana ; Mclaughlin, Lesley A. ; Lin, De ; Henderson, Colin J. ; Wolf, C. Roland (2015)
Drug Metabolism and Disposition. Bethesda : ASPET. 43 (2015), H. 11. Seite: 1679 - 1690
Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms OPUS
Hough, Lindsay B. ; Nalwalk, Julia W. ; Ding, Xinxin ; Scheer, Nico (2015)
Drug Metabolism and Disposition. . 43 (2015), H. 9. Seite: 1326 - 1330
Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo s OPUS
Henderson, Colin J. ; Mclaughlin, Lesley A. ; Scheer, Nico ; Stanley, Lesley A. ; Wolf, C. Roland (2015)
Molecular Pharmacology. Bethesda : ASPET. 87 (2015), H. 4. Seite: 733 - 739
Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism OPUS
Scheer, Nico ; Mclaughlin, Lesley A. ; Rode, Anja ; MacLeod, Alastair Kenneth ; Henderson, Colin J. ; Wolf, Roland C. (2014)
Drug Metabolism and Disposition. Bethesda, Md. : ASPET. 42 (2014), H. 6. Seite: 1022 - 1030
Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications OPUS
Scheer, Nico ; Wolf, C. Roland (2014)
Xenobiotica. Abingdon : Taylor & Francis. 44 (2014), H. 2. Seite: 96 - 108
Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors OPUS
Luisier, Raphaëlle ; Lempiäinen, Harri ; Scherbichler, Nina ; Braeuning, Albert ; Geissler, Miriam ; Dubost, Valerie ; Müller, Arne ; Scheer, Nico ; Chibout, Salah-Dine ; Hara, Hisanori ; Picard, Frank ; Theil, Diethilde ; Couttet, Philippe ; Vitobello, Antonio ; Grenet, Olivier ; Grasl-Kraupp, Bettina ; Ellinger-Ziegelbauer, Heidrung ; Thomson, John P. ; Meehan, Richard R. ; Elcombe, Clifford R. ; Henderson, Colin J. ; Wolf, C. Roland ; Schwarz, Michael ; Moulin, Pierre ; Terranova, Remi ; Moggs, Jonathan G. (2014)
Toxicological Sciences. Oxford : Oxford University Press. 139 (2014), H. 2. Seite: 501 - 511
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins OPUS
Salpati, Laurent ; Chu, Xiaoyan ; Chen, Liangfu ; Prasad, Bhagwat ; Dallas, Shannon ; Evers, Raymond ; Mamaril-Fishman, Donna ; Geier, Ethan G. ; Kehler, Jonathan ; Kunta, Jeevan ; Mezler, Mario ; Laplanche, Loic ; Pang, Jodie ; Soars, Matthew G. ; Unadkat, Jashvant D. ; van Waterschoot, Robert A.B. ; Yabut, Jocelyn ; Schinkel, Alfred H. ; Scheer, Nico ; Rode, Anja (2014)
Drug Metabolism and Disposition. Bethesda, Md. : ASPET. 42 (2014), H. 8. Seite: 1301 - 1313
Xenobiotic receptor humanized mice and their utility OPUS
Scheer, Nico ; Wolf, C. Roland (2013)
Drug Metabolism Reviews. London : Taylor & Francis. (2013), H. 1. Seite: 110 - 121
Generation and utility of genetically humanized mouse models OPUS
Scheer, Nico ; Snaith, Mike ; Wolf, C. Roland ; Seibler, Jost (2013)
Drug Discovery Today. Amsterdam : Elsevier. Vol 18 (2013), H. 23-24. Seite: 1200 - 1211
Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line OPUS
Scheer, Nico ; Balimane, Praveen ; Hayward, Michael D. ; Buechel, Sandra ; Kauselmann, Gunther ; Wolf, C. Roland (2012)
Drug Metabolism and Disposition. Bethesda, Md. : ASPET. 40 (2012), H. 11. Seite: 2212 - 2218
Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines OPUS
Scheer, Nico ; Kapelyukh, Yury ; Rode, Anja ; Buechel, Sandra ; Wolf, C. Roland (2012)
Molecular Pharmacology. Bethesda, Md. : ASPET. 82 (2012), H. 6. Seite: 1022 - 1029
Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion OPUS
Lempiäinen, Harri ; Couttet, Philippe ; Bolognani, Federico ; Müller, Arne ; Dubost, Valérie ; Luisier, Raphaëlle ; Rio-Espinola, Alberto del ; Vitry, Veronique ; Unterberger, Elif B. ; Thomson, John P. ; Treindl, Fridolin ; Metzger, Ute ; Wrzodek, Clemens ; Hahne, Florian ; Zollinger, Tulipan ; Brasa, Sarah ; Kalteis, Magdalena ; Marcellin, Magali ; Giudicelli, Fanny ; Braeuning, Albert ; Morawiec, Laurent ; Zamurovic, Natasa ; Längle, Ulrich ; Scheer, Nico ; Schübeler, Dirk ; Goodman, Jay ; Chibout, Salah-Dine ; Marlowe, Jennifer ; Theil, Dietlinde ; Heard, David J. ; Grenet, Olivier ; Zell, Andreas ; Templin, Markus F. ; Meehan, Richard R. ; Wolf, Roland C. ; Elcombe, Clifford R. ; Schwarz, Michael ; Moulin, Pierre ; Terranova, Rémi ; Moggs, Jonathan G. (2012)
Toxicological Sciences. Oxford : Oxford University Press. 131 (2012), H. 2. Seite: 375 - 386
Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines OPUS
Scheer, Nico ; Kapelyukh, Yury ; McEwan, Jillian ; Beuger, Vincent ; Stanley, Lesley A. ; Rode, Anja ; Wolf, C. Roland (2012)
Molecular Pharmacology. Bethesda, Md. : ASPET. 81 (2012), H. 1. Seite: 63 - 72
Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line OPUS
Hasegawa, Maki ; Kapelyukh, Yury ; Tahara, Harunobu ; Seibler, Jost ; Rode, Anja ; Krueger, Sylvia ; Lee, Dongtao N. ; Wolf, C. Roland ; Scheer, Nico (2011)
Molecular Pharmacology. Bethesda, Md. : ASPET. 80 (2011), H. 33. Seite: 518 - 528
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo OPUS
Ross, Jillian ; Plummer, Simon M. ; Rode, Anja ; Scheer, Nico ; Bower, Conrad C. ; Vogel, Ortwin ; Henderson, Colin J. ; Wolf, C. Roland ; Elcombe, Clifford R. (2010)
Toxicological Sciences. Oxford : Oxford University Press. 116 (2010), H. 2. Seite: 452 - 466
In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice OPUS
Scheer, Nico ; Ross, Jillian ; Kapelyukh, Yury ; Rode, Anja ; Wolf, C. Roland (2010)
Drug Metabolism and Disposition. Bethesda : ASPET. 38 (2010), H. 7. Seite: 1046 - 1053
The use of transgenic animals to study drug metabolism OPUS
Buch-Cover
Henderson, Colin J. ; Wolf, C. Roland ; Scheer, Nico (2009)
Handbook of Drug Metabolism. 2nd Edition. New York : Informa Healthcare 2009. Seite: 637 - 658
Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man OPUS
Henderson, Colin J. ; Scheer, Nico ; Wolf, C. Roland (2009)
Expert Review of Clinical Pharmacology. London : Taylor & Francis Seite: 105 - 109
Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior OPUS
Stanley, Lesley A. ; Horsburgh, Brian C. ; Ross, Jillian ; Scheer, Nico ; Wolf, C. Roland (2009)
Drug Metabolism Reviews. London : Taylor & Francis Seite: 27 - 65
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response OPUS
Scheer, Nico ; Ross, Jillian ; Rode, Anja ; Zevnik, Branko ; Niehaves, Sandra ; Faust, Nicole ; Wolf, C. Roland (2008)
Journal of Clinical Investigation. Ann Arbor, Mich. : American Society for Clinical Investigation Seite: 3228 - 3239
Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio OPUS
Reugels, Alexander M. ; Boggetti, Barbara ; Scheer, Nico ; Campos-Ortega, José A. (2006)
Developmental Dynamics. Seite: 934 - 948
Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity OPUS
Stanley, Lesley A. ; Horsburgh, Brian C. ; Ross, Jillian ; Scheer, Nico ; Wolf, C. Roland (2006)
Drug Metabolism Reviews. Seite: 515 - 597
her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling OPUS
Hans, Stefan ; Scheer, Nico ; Riedl, Iris ; Weizäcker, Elisabeth von ; Blader, Patrick ; Campos-Ortega, José A. (2004)
Development. Seite: 2957 - 2969
A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish OPUS
Scheer, Nico ; Riedl, Iris ; Warren, J.T. ; Kuwada, John Y. ; Campos-Ortega, José A. (2002)
Mechanism of Development. Seite: 9 - 14
Notch signaling is required for arterial-venous differentiation during embryonic vascular development OPUS
Lawson, Nathan D. ; Scheer, Nico ; Pham, Van N. ; Kim, Ceol-Hee ; Chitnis, Ajay B. ; Campos-Ortega, José A. ; Weinstein, Brant M. (2001)
Development. Seite: 3675 - 3683
An instructive function for Notch in promoting gliogenesis in the zebrafish retina OPUS
Scheer, Nico ; Groth, Anne ; Hans, Stefan ; Campos-Ortega, José A. (2001)
Development. Seite: 1099 - 1107
Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins OPUS
Halbach, Thorsten ; Scheer, Nico (2000)
Nucleic Acids Research. Seite: 3542 - 3550
Use of the Gal4-UAS technique for targeted gene expression in the zebrafish OPUS
Scheer, Nico ; Campos-Ortega, José A. (1999)
Mechanism of Development. Seite: 153 - 158
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