Veröffentlichungen

Prof. Dr. rer. nat. Nico Scheer

TitelHumanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
AutorenKazuki, Yasuhiro ; Kobayashi, Kaoru ; Hirabayashi, Masumi ; Abe, Satoshi ; Kajitani, Naoyo ; Kazuki, Kanoko ; Takehara, Shoko ; Takiguchi, Masato ; Satoh, Daisuke ; Kuze, Jiro ; Sakuma, Tetsushi ; Kaneko, Takehito ; Mashimo, Tomoji ; Osamura, Minori ; Hashimoto, Mari ; Wakatsuki, Riko ; Hirashima, Rika ; Fujiwara, Ryoichi ; Deguchi, Tsuneo ; Kurihara, Atsushi ; Tsukazaki, Yasuko ; Senda, Naoto ; Yamamoto, Takashi ; Scheer, Nico ; Oshimura, Mitsuo
ErschienenPNAS Proceedings of the National Academy of Sciences of the United States of America. 2019. Seite: 3072 - 3081
ISBN / ISSN1091-6490
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TitelAn extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials
AutorenScheer, Nico ; Henderson, Colin James ; Kapelyukh, Yury ; Rode, Anja ; Mclaren, Aileen W. ; MacLeod, Alastair Kenneth ; Lin, De ; Wright, Jayne ; Stanley, Lesley ; Wolf, C. Roland
ErschienenDrug Metabolism and Disposition. (2019), H. Early view. - 69 Seiten
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TitelDefining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
AutorenKapelyukh, Yury ; Henderson, Colin James ; Scheer, Nico ; Rode, Anja ; Wolf, Charles Roland
ErschienenDrug Metabolism and Disposition. (2019), H. Early view. - 43 Seiten
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TitelThe pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
AutorenWilson, C. E. ; Dickie, A. P. ; Schreiter, K. ; Wehr, R. ; Wilson, E. M. ; Bial, J. ; Scheer, Nico ; Wilson, I. D. ; Riley, R. J.
ErschienenArchives of Toxicology. 92 (2018), H. 6. Seite: 1953 - 1967
ISBN / ISSN1432-0738
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TitelThe Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
AutorenWilson, Ian D. ; Wilson, Claire E. ; Scheer, Nico ; Dickie, A.P. ; Schreiter, K. ; Wilson, E. M. ; Riley, R. J. ; Wehr, R. ; Bial, J.
ErschienenBiochemical pharmacology. Volume 135 (2017). Seite: 139 - 150
ISBN / ISSN1873-2968
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TitelGenetically Humanized Animal Models
AutorenSamuelsson, K. ; Scheer, Nico ; Wilson, I. ; Wolf, C.R. ; Henderson, C.J.
ErschienenComprehensive Medicinal Chemistry III. 3rd Edition. Saint Louis : Elsevier 2017. Seite: 130 - 149
ISBN / ISSN978-0-12-803201-5
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TitelClinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling
AutorenZhang, Jin ; Heimbach, Tycho ; Scheer, Nico ; Barve, Avantika ; Li, Wenkui ; Lin, Wen ; He, Handan
ErschienenJournal of Pharmaceutical Sciences. Volume 105 (2016), H. Issue 4. Seite: 1398 - 1404
ISBN / ISSN0022-3549
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TitelGeneration and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model
AutorenDallas, Shannon ; Salphati, Laurent ; Gomez-Zepeda, David ; Wanek, Thomas ; Chen, Liangfu ; Chu, Xiaoyan ; Kunta, Jeevan ; Mezler, Mario ; Menet, Marie-Claude ; Chasseigneaux, Stephanie ; Declèves, Xavier ; Langer, Oliver ; Pierre, Esaie ; DiLoreto, Karen ; Hoft, Carolin ; Laplanche, Loic ; Pang, Jodie ; Pereira, Tony ; Andonian, Clara ; Simic, Damir ; Rode, Anja ; Yabut, Jocelyn ; Zhang, Xiaolin ; Scheer, Nico
ErschienenMolecular Pharmacology. 89 (2016), H. 5. Seite: 492 - 504
ISBN / ISSN1521-0111
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TitelA comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
AutorenScheer, Nico ; Wilson, Ian D.
ErschienenDrug Discovery Today. 21 (2016), H. 2. Seite: 250 - 263
ISBN / ISSN1359-6446
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TitelKnockout and humanized animal models to study membrane transporters in drug development
AutorenScheer, Nico ; Chu, Xiaoyan ; Salphati, Laurent ; Zamek-Gliszczynski, Maciej J.
ErschienenDrug Transporters: Volume 1: Role and Importance in ADME and Drug Development. Cambridge : Royal Society of Chemistry 2016. Seite: 298 - 332
ISBN / ISSN978-1-78262-379-3
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TitelDefining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model
AutorenScheer, Nico ; Kapelyukh, Yury ; Rode, Anja ; Oswald, Stefan ; Busch, Diana ; Mclaughlin, Lesley A. ; Lin, De ; Henderson, Colin J. ; Wolf, C. Roland
ErschienenDrug Metabolism and Disposition. 43 (2015), H. 11. Seite: 1679 - 1690
ISBN / ISSN1521-009x
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TitelOpioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms
AutorenHough, Lindsay B. ; Nalwalk, Julia W. ; Ding, Xinxin ; Scheer, Nico
ErschienenDrug Metabolism and Disposition. 43 (2015), H. 9. Seite: 1326 - 1330
ISBN / ISSN1521-009x
Zugriff weltweit
TitelCytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo s
AutorenHenderson, Colin J. ; Mclaughlin, Lesley A. ; Scheer, Nico ; Stanley, Lesley A. ; Wolf, C. Roland
ErschienenMolecular Pharmacology. 87 (2015), H. 4. Seite: 733 - 739
ISBN / ISSN1521-0111
Zugriff weltweit
TitelApplication of Humanised and Other Transgenic Models to Predict Human Responses to Drugs
AutorenWolf, C. Roland ; Kapelyukh, Yury ; Scheer, Nico ; Henderson, Colin J.
ErschienenCambridge : RSC Publ. 2015. Seite: 152 - 176
ISBN / ISSN978-1-78262-778-4
Zugriff campus
TitelDeletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism
AutorenScheer, Nico ; Mclaughlin, Lesley A. ; Rode, Anja ; MacLeod, Alastair Kenneth ; Henderson, Colin J. ; Wolf, Roland C.
ErschienenDrug Metabolism and Disposition. 42 (2014), H. 6. Seite: 1022 - 1030
ISBN / ISSN1521-009x
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TitelPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
AutorenLuisier, Raphaëlle ; Lempiäinen, Harri ; Scherbichler, Nina ; Braeuning, Albert ; Geissler, Miriam ; Dubost, Valerie ; Müller, Arne ; Scheer, Nico ; Chibout, Salah-Dine ; Hara, Hisanori ; Picard, Frank ; Theil, Diethilde ; Couttet, Philippe ; Vitobello, Antonio ; Grenet, Olivier ; Grasl-Kraupp, Bettina ; Ellinger-Ziegelbauer, Heidrung ; Thomson, John P. ; Meehan, Richard R. ; Elcombe, Clifford R. ; Henderson, Colin J. ; Wolf, C. Roland ; Schwarz, Michael ; Moulin, Pierre ; Terranova, Remi ; Moggs, Jonathan G.
ErschienenToxicological Sciences. 139 (2014), H. 2. Seite: 501 - 511
ISBN / ISSN1094-2025
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TitelEvaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
AutorenSalpati, Laurent ; Chu, Xiaoyan ; Chen, Liangfu ; Prasad, Bhagwat ; Dallas, Shannon ; Evers, Raymond ; Mamaril-Fishman, Donna ; Geier, Ethan G. ; Kehler, Jonathan ; Kunta, Jeevan ; Mezler, Mario ; Laplanche, Loic ; Pang, Jodie ; Soars, Matthew G. ; Unadkat, Jashvant D. ; van Waterschoot, Robert A.B. ; Yabut, Jocelyn ; Schinkel, Alfred H. ; Scheer, Nico ; Rode, Anja
ErschienenDrug Metabolism and Disposition. 42 (2014), H. 8. Seite: 1301 - 1313
ISBN / ISSN1521-009X
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TitelGenetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
AutorenScheer, Nico ; Wolf, C. Roland
ErschienenXenobiotica. 44 (2014), H. 2. Seite: 96 - 108
ISBN / ISSN1366-5928
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TitelGeneration and utility of genetically humanized mouse models
AutorenScheer, Nico ; Snaith, Mike ; Wolf, C. Roland ; Seibler, Jost
ErschienenDrug Discovery Today. Vol 18 (2013), H. 23-24. Seite: 1200 - 1211
ISBN / ISSN1359-6446
Zugriff campus
TitelXenobiotic receptor humanized mice and their utility
AutorenScheer, Nico ; Wolf, C. Roland
ErschienenDrug Metabolism Reviews. (2013), H. 1. Seite: 110 - 121
ISBN / ISSN1097-9883
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TitelGeneration and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
AutorenScheer, Nico ; Balimane, Praveen ; Hayward, Michael D. ; Buechel, Sandra ; Kauselmann, Gunther ; Wolf, C. Roland
ErschienenDrug Metabolism and Disposition. 40 (2012), H. 11. Seite: 2212 - 2218
ISBN / ISSN1521-0111
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TitelGeneration and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines
AutorenScheer, Nico ; Kapelyukh, Yury ; Rode, Anja ; Buechel, Sandra ; Wolf, C. Roland
ErschienenMolecular Pharmacology. 82 (2012), H. 6. Seite: 1022 - 1029
ISBN / ISSN1521-0111
Zugriff weltweit
TitelIdentification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion
AutorenLempiäinen, Harri ; Couttet, Philippe ; Bolognani, Federico ; Müller, Arne ; Dubost, Valérie ; Luisier, Raphaëlle ; Rio-Espinola, Alberto del ; Vitry, Veronique ; Unterberger, Elif B. ; Thomson, John P. ; Treindl, Fridolin ; Metzger, Ute ; Wrzodek, Clemens ; Hahne, Florian ; Zollinger, Tulipan ; Brasa, Sarah ; Kalteis, Magdalena ; Marcellin, Magali ; Giudicelli, Fanny ; Braeuning, Albert ; Morawiec, Laurent ; Zamurovic, Natasa ; Längle, Ulrich ; Scheer, Nico ; Schübeler, Dirk ; Goodman, Jay ; Chibout, Salah-Dine ; Marlowe, Jennifer ; Theil, Dietlinde ; Heard, David J. ; Grenet, Olivier ; Zell, Andreas ; Templin, Markus F. ; Meehan, Richard R. ; Wolf, Roland C. ; Elcombe, Clifford R. ; Schwarz, Michael ; Moulin, Pierre ; Terranova, Rémi ; Moggs, Jonathan G.
ErschienenToxicological Sciences. 131 (2012), H. 2. Seite: 375 - 386
ISBN / ISSN1094-2025
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TitelModeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
AutorenScheer, Nico ; Kapelyukh, Yury ; McEwan, Jillian ; Beuger, Vincent ; Stanley, Lesley A. ; Rode, Anja ; Wolf, C. Roland
ErschienenMolecular Pharmacology. 81 (2012), H. 1. Seite: 63 - 72
ISBN / ISSN1521-0111
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TitelQuantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
AutorenHasegawa, Maki ; Kapelyukh, Yury ; Tahara, Harunobu ; Seibler, Jost ; Rode, Anja ; Krueger, Sylvia ; Lee, Dongtao N. ; Wolf, C. Roland ; Scheer, Nico
ErschienenMolecular Pharmacology. 80 (2011), H. 33. Seite: 518 - 528
ISBN / ISSN1521-0111
Zugriff weltweit
TitelHuman constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
AutorenRoss, Jillian ; Plummer, Simon M. ; Rode, Anja ; Scheer, Nico ; Bower, Conrad C. ; Vogel, Ortwin ; Henderson, Colin J. ; Wolf, C. Roland ; Elcombe, Clifford R.
ErschienenToxicological Sciences. 116 (2010), H. 2. Seite: 452 - 466
ISBN / ISSN1096-0929
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TitelIn vivo responses of the human and murine pregnane X receptor to dexamethasone in mice
AutorenScheer, Nico ; Ross, Jillian ; Kapelyukh, Yury ; Rode, Anja ; Wolf, C. Roland
ErschienenDrug Metabolism and Disposition. 38 (2010), H. 7. Seite: 1046 - 1053
ISBN / ISSN1521-009X
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TitelAdvances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man
AutorenHenderson, Colin J. ; Scheer, Nico ; Wolf, C. Roland
ErschienenExpert Review of Clinical Pharmacology. 2 (2009), H. 2. Seite: 105 - 109
ISBN / ISSN1751-2441
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TitelDrug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
AutorenStanley, Lesley A. ; Horsburgh, Brian C. ; Ross, Jillian ; Scheer, Nico ; Wolf, C. Roland
ErschienenDrug Metabolism Reviews. 41 (2009), H. 1. Seite: 27 - 65
ISBN / ISSN1097-9883
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TitelThe use of transgenic animals to study drug metabolism
AutorenHenderson, Colin J. ; Wolf, C. Roland ; Scheer, Nico
ErschienenHandbook of Drug Metabolism. 2nd Edition. New York : Informa Healthcare 2009. Seite: 637 - 658
ISBN / ISSN978-1-4200-7647-9
TitelA novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
AutorenScheer, Nico ; Ross, Jillian ; Rode, Anja ; Zevnik, Branko ; Niehaves, Sandra ; Faust, Nicole ; Wolf, C. Roland
ErschienenJournal of Clinical Investigation. 118 (2008), H. 9. Seite: 3228 - 3239
ISBN / ISSN1558-8238
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TitelAsymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio
AutorenReugels, Alexander M. ; Boggetti, Barbara ; Scheer, Nico ; Campos-Ortega, José A.
ErschienenDevelopmental Dynamics. 235 (2006), H. 4. Seite: 934 - 948
ISBN / ISSN1097-0177
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TitelNuclear Receptors which play a pivotal role in drug disposition and chemical toxicity
AutorenStanley, Lesley A. ; Horsburgh, Brian C. ; Ross, Jillian ; Scheer, Nico ; Wolf, C. Roland
ErschienenDrug Metabolism Reviews. 38 (2006), H. 3. Seite: 515 - 597
ISBN / ISSN1097-9883
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Titelher3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling
AutorenHans, Stefan ; Scheer, Nico ; Riedl, Iris ; Weizäcker, Elisabeth von ; Blader, Patrick ; Campos-Ortega, José A.
ErschienenDevelopment. 131 (2004), H. 12. Seite: 2957 - 2969
ISBN / ISSN1477-9129
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TitelA quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish
AutorenScheer, Nico ; Riedl, Iris ; Warren, J.T. ; Kuwada, John Y. ; Campos-Ortega, José A.
ErschienenMechanism of Development. 112 (2002), H. 1-2. Seite: 9 - 14
ISBN / ISSN0925-4773
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TitelNotch signaling is required for arterial-venous differentiation during embryonic vascular development
AutorenLawson, Nathan D. ; Scheer, Nico ; Pham, Van N. ; Kim, Ceol-Hee ; Chitnis, Ajay B. ; Campos-Ortega, José A. ; Weinstein, Brant M.
ErschienenDevelopment. 128 (2001), H. 19. Seite: 3675 - 3683
ISBN / ISSN1477-9129
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TitelAn instructive function for Notch in promoting gliogenesis in the zebrafish retina
AutorenScheer, Nico ; Groth, Anne ; Hans, Stefan ; Campos-Ortega, José A.
ErschienenDevelopment. 128 (2001), H. 7. Seite: 1099 - 1107
ISBN / ISSN0950-1991
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TitelTranscriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins
AutorenHalbach, Thorsten ; Scheer, Nico
ErschienenNucleic Acids Research. 28 (2000), H. 18. Seite: 3542 - 3550
ISBN / ISSN1362-4962
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TitelUse of the Gal4-UAS technique for targeted gene expression in the zebrafish
AutorenScheer, Nico ; Campos-Ortega, José A.
ErschienenMechanism of Development. 80 (1999), H. 2. Seite: 153 - 158
ISBN / ISSN0925-4773
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